Table 3 Multiple linear regression for the association of T cells related cytokines and factors with metabolic syndrome as dependant variable.

From: Premature thymic functional senescence is a hallmark of childhood acute lymphoblastic leukemia survivorship

Dependant variable

Metabolic syndrome

covariates

Unadjusted, B (95% CI); p

Adjusted for age and sex

All covariates, B (95% CI); p

Selected covariates, B (95% CI); p

Chronoage

0.009 (0.003 to 0.015), p = 0.002

–

0.007 (0.001 to 0.013), p = 0.02

0.008 (0.002 to 0.013), p = 0.008

Gender

−0.018 (−0.091 to 0.055), p = 0.63

–

−0.004 (−0.076 to 0.067), p = 0.91

−0.009 (−0.080 to 0.062), p = 0.81

IL6, n = 246

0.143 (0.037 to 0.249), p = 0.009

0.130 (0.025 to 0.236), p = 0.016

0.160 (0.046 to 0.274), p = 0.006

0.121 (0.014 to 0.228), p = 0.027

IL7, n = 246

−0.115 (−0.275 to 0.044), p = 0.16

−0.101 (−0.259 to 0.056), p = 0.21

−0.018 (−0.189 to 0.153), p = 0.84

–

IL15, n = 246

−0.225 (−0.648 to 0.198), p = 0.30

−0.269 (−0.688 to 0.150), p = 0.21

−0.168 (−0.632 to 0.296), p = 0.48

–

GM-CSF, n = 246

−0.011 (−0.097 to 0.076), p = 0.80

0.005 (−0.080 to 0.091), p = 0.90

0.001 (−0.087 to 0.088), p = 0.99

–

IL-4, n = 246

0.152 (0.005 to 0.300), p = 0.04

0.135 (−0.011 to 0.281), p = 0.07

0.101 (−0.050 to 0.252), p = 0.19

0.114 (−0.034 to 0.262), p = 0.13

bFGF, n = 246

−0.033 (−0.145 to 0.079), p = 0.56

−0.026 (−0.136 to 0.084), p = 0.64

−0.045 (−0.156 to 0.066), p = 0.43

–

INFy, n = 246

−0.049 (−0.113 to 0.016), p = 0.14

−0.038 (−0.102 to 0.026), p = 0.24

−0.052 (−0.122 to 0.019), p = 0.15

–

Il-12p70, n = 246

−0.152 (−0.303 to 0.00), p = 0.050

−0.134 (−0.285 to 0.016), p = 0.08

−0.140 (−0.292 to 0.013), p = 0.07

−0.157 (−0.306 to −0.008), p = 0.038

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