Fig. 2: Concentration of serum cytokines, number of NK cells, and neutrophils in peripheral blood at the indicated time points after CAR-T cell infusion.
From: Anti-CD5 CAR-T cells with a tEGFR safety switch exhibit potent toxicity control
A Concentration of cytokines, including IL-10 (ranging between 5.0–26.7 pg/mL, 5.0–13.3 pg/mL, and 5.0–38.8 pg/mL in patients 1–3, respectively), IL-1β (ranging between 5.0–9.6 pg/mL, 5.0–10.7 pg/mL, and 7.5–35.4 pg/mL in patients 1–3, respectively), IL-6 (ranging between 1.5–116.7 pg/mL, 1.5–34.9 pg/mL and 3.95–103.3 pg/mL in patients 1–3, respectively), IL-8 (ranging between 5.3–92.3 pg/mL, 11.5–129.0 pg/mL, and 19.1–107.0 pg/mL in patients 1–3, respectively), and TNF-α (ranging between 9.8–48.1 pg/mL, 10.4–111.0 pg/mL, and 10.4–39.5 pg/mL in patients 1–3, respectively), as well as two acute phase proteins, ferritin (ranging between 67.7–573.5 μg/L, 539.8–935.9 μg/L, and 459.6–2181.2 μg/L in patients 1–3, respectively) and hypersensitive C-reactive protein (ranging between 0.1–116.0 mg/L, 1.0–73.8 mg/L, and 6.5–148.6 mg/L in patients 1–3, respectively), at various time points after CAR-T cell infusion. Note: Detection limits for IL-10, IL-1β, and IL-6 are 5.0 pg/mL, 5.0 pg/mL, and 1.5 pg/mL, respectively, when concentrations fall below these limits, the default value is set to the detection limit. All other values in the figure are within the detectable range; B, C Absolute numbers of NK cells (B) and neutrophils (C) in the peripheral blood of the three patients within 28 days post-infusion. During cetuximab administration in three patients, the number of NK cells per liter was 7.12 × 107 at day 14, 4.67 × 107 at day 13, and 2.21 × 107 at day 21. The number of neutrophils ranged between 0.62 × 109–4.47 × 109, 0.05 × 109–0.16 × 109, and 0.27 × 109–2.04 × 109.
