Table 1 When to initiate IgG-RT.

From: IgG replacement in multiple myeloma

2022 AAAAI Work Group Report for Secondary HG

• IgG < 400 mg/dL with recurrent infections

• IgG < 700 mg/dL with recurrent infections, in addition to low IgA or IgM, and impaired vaccine responses

• IgG < 150 mg/dL

HCT guidelines

• Not routinely recommended, but can be considered if IgG <400 mg/dL

ASBMT

• Recommend against IgG-RT if no history of recurrent infection, regardless of IgG level

Hill et al.

• Check serum IgG prior to and within 3 months post-CAR T cell therapy and consider if IgG is ≤400 mg/dL

• IgG 400–600 mg/dL with serious recurrent infections

• IgG > 600 mg/dL with impaired vaccine responses

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