Table 4 IgG-RT dosing and IgG goal.

From: IgG replacement in multiple myeloma

Kampouri et al.

• IVIG 400 mg/kg every 3–4 weeks or SCIG 100–200 mg/kg/week

• IgG trough >400 mg/dL for first 3 months after CAR T therapy

2022 AAAAI Work Group Report

• IVIG 400–600 mg/kg/month or SCIG 100–200 mg/kg/week

• IgG trough >800 mg/dL (>1000 mg/dL if recurrent pulmonary infections)

• Titrate to clinical improvement

Hill et al., Bonagura et al.

• IVIG 400–800 mg/kg every 3–4 weeks or SCIG 100–200 mg/kg/week

• IgG trough >400 mg/dL

• Titrate to clinical improvement

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