Table 5 Considerations for discontinuing IgG-RT.

From: IgG replacement in multiple myeloma

• Consider pausing IgG-RT 9–12 months after discontinuation of B cell-depleting therapy

• Monitor for endogenous recovery of CD19+ B cells, CD20+ B cells, IgG, IgM, and IgA

• Able to maintain IgG ≥400 mg/dL for three consecutive months off IgG-RT without evidence of recurrent bacterial infections

• Protective vaccine responses checked 3–4 months after IgG-RT discontinuation

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