Fig. 1: Transcriptomics defined three distinct subgroups in t(8;21) AML. | Blood Cancer Journal

Fig. 1: Transcriptomics defined three distinct subgroups in t(8;21) AML.

From: Multiomic analysis identifies a high-risk subgroup that predicts poor prognosis in t(8;21) acute myeloid leukemia

Fig. 1

A Gene expression heatmap of three molecular categories in t(8;21) AML determined by consensus hierarchical clustering. Molecular subtypes and clustering confidence scores are displayed in the tracks. B Enrichment plots of each cluster. Columns showing the normalized enrichment scores (NES) and FDR q value of geneset enrichment by GSEA. C Heatmap for visualization of cell differentiation stages of each molecular subgroup by GSVA. D Genetic alterations in each cluster. Transcriptional clusters and gene mutations are shown for each sample. KIT others: KIT mutation except for KIT-D816 and KIT-N822.

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