Fig. 1: IG and CCND1 breakpoints. | Blood Cancer Journal

Fig. 1: IG and CCND1 breakpoints.

From: Large B-cell lymphomas with CCND1 rearrangement have different immunoglobulin gene breakpoints and genomic profile than mantle cell lymphoma

Fig. 1

A Schematic representation of the location of the breakpoints found in the IG loci (IGH, top, IGL, bottom). CSR, class-switch recombination region. IGHJ genes (1–6) are shown as a single gene due to their small size and compactness for illustrative purposes. Genomic locations are shown on the x axis. Breakpoints are colored based on their underlying mechanism as AID-mediated through aberrant CSR/SHM or RAG-mediated during the initial J-D recombination. B Representation of the breakpoints found in chromosome 11. MTC major translocation cluster.

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