Fig. 4: SMZL and transformed LBCL with CSR-mediated CCND1 rearrangement. | Blood Cancer Journal

Fig. 4: SMZL and transformed LBCL with CSR-mediated CCND1 rearrangement.

From: Large B-cell lymphomas with CCND1 rearrangement have different immunoglobulin gene breakpoints and genomic profile than mantle cell lymphoma

Fig. 4

A Splenic marginal zone lymphoma with expansion of the marginal areas of the white pulp (H&E stain, original magnification ×100). B Cyclin D1 staining was negative (immunoperoxidase, original magnification ×200). C Lymph node with diffuse large B-cell lymphoma obtained 14 years later. Both tumors had the same clonal IGHV1-2*04 - IGHD3-10*01 - IGHJ6*02 rearrangement (H&E stain, original magnification ×200). D The transformed tumor was positive for cyclin D1 in the large cells but also in occasional atypical smaller cells (immunoperoxidase, original magnification ×200).

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