Table 1 Individual Drugs Used in Common SOC Chemotherapy in Newly Diagnosed Adult Patients With Ph-Negative BCP-ALL.
Chemotherapeutic Agent | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Common Regimen | Country | Vinca Alkaloid | Anthracycline | Corticosteroid | Asparaginase | Alkylating Agent | Antimetabolite | Topoisomerase Inhibitor | Rituximab* |
CALGB 10403† [69] | US | Vincristine | Daunorubicin Doxorubicin | Prednisone Dexamethasone | Pegaspargase | Cyclophosphamide | Methotrexate (systemic and IT) Cytarabine (systemic and IT) 6-mercaptopurine 6-thioguanine | ||
DFCI ALL† [70] | US | Vincristine | Doxorubicin | Prednisone Dexamethasone Hydrocortisone (IT) | Asparaginase | Methotrexate (systemic and IT) Cytarabine (IT) 6-mercaptopurine | |||
PETHEMA ALL-96† [71] | Spain | Vincristine | Daunorubicin | Prednisone Dexamethasone Hydrocortisone (IT) | Asparaginase | Cyclophosphamide | Methotrexate (systemic and IT) Cytarabine (systemic and IT) 6-mercaptopurine | Teniposide | |
Hyper-CVAD [72]† | US/Australia | Vincristine | Doxorubicin | Prednisone Dexamethasone Methylprednisolone | Cyclophosphamide | Methotrexate (systemic and IT) Cytarabine (systemic and IT) 6-mercaptopurine | |||
USC/MSKCC ALL† [73] | US | Vincristine | Daunorubicin | Prednisone Dexamethasone | Pegaspargase | Cyclophosphamide | Methotrexate (systemic and IT) Cytarabine 6-mercaptopurine 6-thioguanine | Teniposide | |
Linker 4-drug regimen [74] | US | Vincristine | Daunorubicin | Prednisone | Asparaginase | Methotrexate (systemic and IT) Cytarabine 6-mercaptopurine | Etoposide | ||
CALGB 8811 Larson [75] | US | Vincristine | Daunorubicin Doxorubicin | Prednisone Dexamethasone | L-asparaginase | Cyclophosphamide | Methotrexate (systemic and IT) Cytarabine 6-mercaptopurine 6-thioguanine | ||
MRC UKALLXII/ ECOG2993 [76] | US/UK | Vincristine | Daunorubicin | Prednisone Dexamethasone | L-asparaginase | Cyclophosphamide | Methotrexate (systemic and IT) Cytarabine 6-mercaptopurine 6-thioguanine | Etoposide | |
Modified DFCI-01 [40] | Canada | Vincristine | Doxorubicin | Dexamethasone | Asparaginase | Methotrexate (systemic and IT) Cytarabine 6-mercaptopurine | |||
GRAALL-2005† [77] | France | Vincristine | Daunorubicin | Prednisone Dexamethasone Methylprednisolone (IT) | L-asparaginase | Cyclophosphamide | Methotrexate (systemic and IT) Cytarabine (systemic and IT) 6-mercaptopurine | Etoposide | Rituximab |
France | Vincristine | Daunorubicin | Prednisone Dexamethasone Methylprednisolone (IT) | L-asparaginase | Cyclophosphamide | Methotrexate (systemic and IT) Cytarabine (systemic and IT) 6-mercaptopurine | Etoposide | ||
Germany | Vincristine | Idarubicin | Dexamethasone | Pegaspargase | Cyclophosphamide | Methotrexate (systemic and IT) Cytarabine 6-mercaptopurine | Rituximab | ||
GIMEMA LAL 1913 [60] | Italy | Vincristine | Idarubicin | Prednisone Dexamethasone (systemic and IT) | Pegaspargase | Cyclophosphamide | Methotrexate (systemic and IT) Cytarabine (systemic and IT) 6-mercaptopurine Dexamethasone (IT) | ||
HOVON-100 [61] | Netherlands, Belgium, France | Vincristine Vindesine | Daunorubicin Doxorubicin | Prednisone Dexamethasone | Pegaspargase | Methotrexate (systemic and IT) Cytarabine 6-mercaptopurine 6-thioguanine | Etoposide | ||
UKALL14 [80] | UK | Vincristine | Daunorubicin | Prednisolone Dexamethasone | Pegaspargase | Cyclophosphamide | Methotrexate (systemic and IT) Cytarabine 6-mercaptopurine | Etoposide | Rituximab |
JALSG 202-0 [81] | Japan | Vincristine | Daunorubicin Doxorubicin | Prednisolone Dexamethasone (systemic and IT) | L-asparaginase | Cyclophosphamide | Methotrexate (systemic and IT) Cytarabine (systemic and IT) 6-mercaptopurine | Etoposide | |
