Table 1 Results of the unweighted score analyses.

MGUS risk

1

218

178

1.00

-

-

182

155

1.00

-

-

2

161

128

0.97

0.70–1.35

0.873

180

151

1.07

0.77–1.48

0.683

3

169

131

1.02

0.74–1.41

0.889

212

177

1.07

0.78–1.45

0.677

4

210

177

1.02

0.76–1.38

0.879

130

111

1.20

0.84–1.71

0.318

5

121

132

1.38

0.98–1.93

0.065

175

152

1.13

0.82–1.57

0.452

Continuous^a

879

746

1.06

0.98–1.14

0.123

879

746

1.04

0.96–1.11

0.356

MM risk

1

494

451

1.00

-

-

393

402

1.00

-

-

2

350

327

1.03

0.82–1.30

0.811

277

274

0.92

0.68–1.23

0.568

3

425

406

1.02

0.82–1.27

0.866

386

463

1.07

0.82–1.40

0.607

4

443

502

1.24

1.01–1.54

0.042

244

296

1.23

0.91–1.65

0.177

5

338

380

1.31

1.04–1.65

0.02

306

416

1.33

1.01–1.74

0.044

Continuous^a

2050

2066

1.07

1.02–1.13

0.005

1606

1851

1.08

1.02–1.15

0.012

Quintile

MGUS

MGUS

OR

95% CI

P_value

MGUS

MGUS

OR

95%CI

P_value

non-progressor

progressor

non-progressor

progressor

MGUS progression to MM^c

1

167

11

1.00

-

-

140

15

1.00

-

-

2

113

15

1.96

0.85–4.48

0.112

143

8

0.49

0.19–1.24

0.131

3

176

19

1.60

0.73–3.51

0.241

158

19

1.24

0.60–2.59

0.563

4

102

11

1.68

0.69–4.07

0.251

104

7

0.64

0.25–1.66

0.364

5

119

13

1.76

0.74–4.18

0.197

132

20

1.47

0.71–3.05

0.303

Continuous^a

677

69

1.1

0.92–1.32

0.301

677

69

1.12

0.94–1.34

0.199

Quintile

Alive

Deceased

HR

95% CI

P_value

Alive

Deceased

HR

95%CI

P_value

MM survival

1

158

69

1.00

-

-

147

77

1.00

-

-

2

183

93

1.08

0.79–1.48

0.629

151

72

0.92

0.66–1.27

0.601

3

119

66

1.25

0.88–1.76

0.208

122

62

0.97

0.69–1.36

0.845

4

97

62

1.19

0.84–1.68

0.339

131

75

1.13

0.82–1.56

0.456

5

119

53

0.92

0.64–1.32

0.636

125

57

0.70

0.49–0.99

0.046

Continuous^a

676

343

0.99

0.92–1.08

0.940

676

343

0.96

0.89–1.03

0.235