Fig. 1: Identification of recurrent driver mutations in AA and EA CLL.
From: Genomic characterization of chronic lymphocytic leukemia in patients of African ancestry
A Heatmap of mutated driver genes stratified by ancestry, treatment prior to sample collection, and IGHV status. The “Mutation Distribution” histogram represents the number of mutated genes per sample, with the type of mutation color-coded by known hotspot missense (yellow), frameshift (red), nonsense (purple), splice site (blue), and multiple mutations (green). B Frequency of mutated CLL driver genes compared between the AA (n = 115) and EA (n = 440) cohorts (black dot = p > 0.05; blue dot = p ≤ 0.05). C Frequency of mutated CLL driver genes compared between the u-IGHV AA (n = 78) and EA (n = 218) cohorts (black dot = p > 0.05; blue dot = p ≤ 0.05).
