Table 2 Primary endpoints of spleen volume response rate >35% (SVR35) and symptom response (reduction in symptoms >50%) at week 24 in a subgroup analysis of patients enrolled in the JAKARTA and JAKARTA-2 trials with low baseline platelets (50 000–100 000/µL) vs high baseline platelets (>100,000/µL).

From: Fedratinib for the treatment of myelofibrosis: a critical appraisal of clinical trial and “real-world” data

 

SVR35

Symptom Response

 

JAKARTA

JAKARTA-2

JAKARTA

JAKARTA-2

High platelet

49%

28%

42%

20%

Low platelet

36%

36%

33%

39%