Fig. 1: Gene mutation profile in patients 60 years and older with AML.

A Common driver gene mutations present in ≥ 10% of the patients. Gene mutations with any detectable VAF were considered present. B Analysis of variant allele frequencies of the top 10 most frequently mutated genes. The boxplots show the median, 25th and 75th percentiles, minimum, maximum, and outliers. The black dashed line marks an allele frequency of 0.5. C Co-occurrence of molecular markers across molecular subgroups. The number at the top of each column is the number of patients belonged to the subclass. Red and blue highlighted boxes indicate significant (FDR-corrected p < 0.05) co-occurrence (red) or mutual exclusively (blue) between two gene mutations or between gene mutations and recurrent cytogenetic abnormalities. P-values were calculated using the Fisher’s exact test and were corrected for the number of patients with available cytogenetics (n = 926/1023). For example, of the 280 patients with complex karyotype, 213 patients also had a TP53 mutation, while 5 patients had a NPM1 mutation.