Fig. 1: Molecular characteristics of TP53 mutations in t-MDS and p-MDS.

A Molecular landscape of 138 t-MDS patients. Each column represents a patient. Mutations are colored according to mutation types as indicated above. TP53 allelic status and recurrent cytogenetic abnormalities (complex karyotype, abnormalities of chromosomes 5, 7, and 17) are shown at the bottom. B Distribution of TP53 mutations along the gene body. Mutations from t-MDS patients are shown at the bottom and those from p-MDS patients at the top, each variant is colored according to mutation type as indicated above. C Molecular landscape and clonal hierarchy of TP53^mut t-MDS (n = 43) and p-MDS (n = 107). Each column represents a patient. Red depicts ancestral events and purple depicts subclonal events. Type of MDS, TP53 allelic status and TP53^mut VAF are shown at the bottom. t-MDS therapy-related myelodysplastic syndromes, p-MDS primary myelodysplastic syndromes, TP53^mut TP53-mutated, VAF variant allele frequency.