Table 2 Patient characteristics by pathogenic variant status overall and by gene.
From: Risk of lymphoid malignancy associated with cancer predisposition genes
No Mutation (N = 6788) | Any Mutation (N = 202) | ATM (N = 57) | CHEK2 (N = 125) | TP53 (N = 20) | |
|---|---|---|---|---|---|
Age | |||||
N | 6660 | 202 | 57 | 125 | 20 |
Median | 63 | 63 | 64 | 62 | 61 |
Range | 18.0–94.0 | 20.0–90.0 | 25.0–90.0 | 20.0–89.0 | 37.0–79.0 |
Age category, N (%) | |||||
Missing | 4 | 0 | 0 | 0 | 0 |
<60 | 2721 (40.1%) | 83 (41.1%) | 20 (35.1%) | 54 (43.2%) | 9 (45.0%) |
60+ | 4063 (59.9%) | 119 (58.9%) | 37 (64.9%) | 71 (56.8%) | 11 (55.0%) |
Sex, N (%) | |||||
Missing | 3 | 0 | 0 | 0 | 0 |
Female | 2812 (41.4%) | 85 (42.1%) | 20 (35.1%) | 59 (47.2%) | 6 (30.0%) |
Male | 3973 (58.6%) | 117 (57.9%) | 37 (64.9%) | 66 (52.8%) | 14 (70.0%) |
Family history of hematologic malignancy, N (%) | |||||
Missing | 2162 | 66 | 19 | 37 | 10 |
No | 3945 (85.3%) | 108 (79.4%) | 31 (81.6%) | 68 (77.3%) | 9 (90.0%) |
Yes | 681 (14.7%) | 28 (20.6%) | 7 (18.4%) | 20 (22.7%) | 1 (10.0%) |
Personal history of prior solid tumor cancer, N (%) | |||||
Missing | 3376 | 100 | 27 | 63 | 10 |
No | 2881 (84.4%) | 82 (80.4%) | 27 (90.0%) | 48 (77.4%) | 7 (70.0%) |
Yes | 531 (15.6%) | 20 (19.6%) | 3 (10.0%) | 14 (22.6%) | 3 (30.0%) |
