Table 1 Patient’s characteristics

From: Clinical outcome of FLAG-IDA chemotherapy sequential with Flu–Bu3 conditioning regimen in patients with refractory AML: a parallel study from Shanghai Institute of Hematology and Institut Paoli-Calmettes

 

Total

RJH

IPC

P

No. of patients

47

27

20

0.22

Sex: Male/female

17/30

11/16

6/14

0.18

Age: median (range)

42(16–62)

34 (16–60)

44 (26–62)

0.001

Disease stage

 Induction failure/early relapse

23/1

14/1

9/0

0.47

 Relapse/refractory

23

12

11

 

Cytogenetic/molecular

   

0.045

Favorable/intermediate/poor/not evaluable

2/18/19/8

1/9/9/8

1/9/10/0

 

Previous chemotherapy median (range)

3(1–10)

4(2–10)

2(1–3)

<0.001

WBC (x109/L)

3.0

4.4

3.0

0.27

Median (range)

(0.3–44)

(0.3–11.1)

(0.7–28.0)

 

Circulating blast (positive/negative)

28/19

17/10

11/9

0.58

BM blast: median (range)

35%(1–90)

56%(1–90)

17.5%(4–79)

0.01

Donor type

 MSD/MUD/Haplo

13/16/16

8/11/8

5/7/8

0.76

 aGvHD prophylaxis

CSA + MTX + MMF ± ATG/PT-Cy + CSA ± MMF

27/20

27/0

0/20

<0.001

DLI post HSCT (yes/no)

13/34

2/25

11/9

<0.001

  1. RJH Rui Jin Hospital, IPC Institut Paoli-Calmettes, BM bone marrow, MSD matched sibling donor, MUD matched unrelated donor, Haplo haplo-identical donor, aGvHD acute graft-versus-host disease, CsA cyclosporine A, MTX methotrexate, MMF mycophenolate mofetil, ATG anti-thymocyte globulin, PT-Cy posttransplant cyclophosphamide, DLI donor lymphocyte infusion