Table 1 Summary of report characteristics, patient demographics, transplant type, and disease parameters

	Study quality factors			Defibrotide-treated			Age			Transplant		Common underlying diseases
Reference*	Prospective?	Type	Control	Total	MOD	No MOD	Median	≤ 16 years	> 16 years	Auto	Allo	ALL	AML	Other
Richardson 1998 [1]	Yes	Single center	No	19	19	0	40	3	16	11	8	1	3	15
Chopra 2000 [2]	Yes	CU	No	40	26	14	30	11	29	14	26	6	14	20
Richardson 2002 [3]	Yes	CU	No	88	88	0	35	29^a	59^a	28	60	6	22	60
Corbacioglu 2004 [4]	No	CU	No	45	22	23	8.2	40	5	8	37	6	10	29
Bulley 2007 [5]	No	Single center	No	14	NR	NR	10.2	14^b	0^b	0	14	3	1	10
Sucak 2007 [6]	No	Single center	No	14	6	8	40.5	0^b	14^b	1	13	4	5	5
Richardson 2010 [7]	Yes	Phase 2, dose finding	No	149	149	0	34	48^a	101^a	20	129	15	47	87
Ruiz Ramos 2014 [8]	No	Observational	No	11	NR	NR	NR	4	5	NR	NR	NR	NR	NR
Locatelli 2015 [9]	Yes	CU	No	98	17	77	13.4	52^a	42^a	10	75	18	23	57
Triplett 2015 [10]	Yes	Single center	No	34	22	12	8.9	31^a	3^a	2	29	10	10	14
Balade Martinez 2016 [11]	No	Observational	No	42	42	0	46	12	30	NR	NR	NR	NR	NR
Corbacioglu 2016 [12]	Yes	CU	No	710	261	348	25	303^a	407^a	112	499	120	177	413
Pol 2016 [13]	No	Single center	No	13	12	1	60.5	0	13	0	13	0	7	6
Richardson 2016 [14]	Yes	Phase 3	Historical	102	102	0	21	44	58	12	90	17	29	56
Strouse 2016 [15]	No	Registry	Not treated	41	41	0	11	25 (61)	16 (39)	2 (5)	39 (95)	19^c		22
Yakushijin 2016 [16]	No	Registry	Thrombo-modulin	24	NR	NR	40	NR	NR	0	65	NR	NR	NR
Richardson 2017 (T-IND) [17]	Yes	T-IND	No	1154	571	NR	12	691	463	155	843	279	279	596

ALL, acute lymphocytic leukemia; Allo, allogeneic; AML, acute myelogenous leukemia; Auto, autologous; CU, compassionate use; MOD, multi-organ dysfunction; NR, not reported; T-IND, defibrotide expanded access program
^aPediatric defined as ≤ 18 years and adults as > 18 years
^bInclusive of age 16 years
^cAcute leukemias
^*These references are listed in accordance with the correction article, however in the original article the reference numbers differ, as they are in accordance with the original article

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