Table 4 Refinement of the disease risk index (DRI, derived from Armand et al, reference 19) as applied to the first phase of the EBMT benchmarking system

From: Benchmarking of survival outcomes following haematopoietic stem cell transplantation: A review of existing processes and the introduction of an international system from the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE)

Disease

Stage

DRI group

Hodgkin lymphoma CR

 

Low

CLL CR

 

Low

Mantle cell lymphoma CR

 

Low

Indolent NHL CR

 

Low

AML favourable cytogenetics CR

 

Low

Indolent NHL PR

 

Low

CLL PR

 

Low

CML chronic phase 1/2

 

Low

CML advanced phase

 

Int

Mantle cell lymphoma PR

 

Int

Myeloproliferative neoplasm

Any

Int

AML intermediate cytogenetics CR

 

Int

ALL CR1

 

Int

T-cell NHL CR

 

Int

Multiple myeloma CR/VGPR/PR

 

Int

Aggressive NHL CR

 

Int

Low-risk MDS adverse cytogenetics

Early

Int

T-cell NHL PR

 

Int

Low-risk MDS intermediate cytogenetics

Early

Int

Hodgkin lymphoma PR

 

Int

Low-risk MDS intermediate cytogenetics

Advanced

Int

Indolent NHL

Advanced

Int

CLL

Advanced

Int

High-risk MDS intermediate cytogenetics

Early

Int

Aggressive NHL PR

 

Int

T-cell NHL

Advanced

High

AML favourable cytogenetics

Advanced

High

Hodgkin lymphoma

Advanced

High

High-risk MDS intermediate cytogenetics

Advanced

High

High-risk MDS adverse cytogenetics

Early

High

ALL CR2

 

High

AML adverse cytogenetics CR

 

High

Mantle cell lymphoma

Advanced

High

High-risk MDS adverse cytogenetics

Advanced

High

Burkitt lymphoma CR

 

High

Multiple myeloma

Advanced

High

ALL CR3

 

High

Low-risk MDS adverse cytogenetics

Advanced

High

AML intermediate cytogenetics

Advanced

High

CML blast phase

 

Very high

ALL

Advanced

Very high

Aggressive NHL

Advanced

Very high

AML adverse cytogenetics

Advanced

Very high

Burkitt lymphoma PR

Advanced

Very high

  1. Advanced stage refers to induction failure or active relapse, including stable or progressive disease for NHL, HL or CLL