Table 1 Clinical outcomes of patients in the two groups.

From: Low dose anti-thymocyte globulin with low dose posttransplant cyclophosphamide (low dose ATG/PTCy) can reduce the risk of graft-versus-host disease as compared with standard-dose anti-thymocyte globulin in haploidentical peripheral hematopoietic stem cell transplantation combined with unrelated cord blood

 

Low dose ATG/PTCy regimen

(n = 31)

Standard-dose ATG regimen

(n = 36)

P

CI of grades I–IV aGvHD at 180 days

49.7%

79.3%

0.065

CI of grades II–IV aGvHD at 180 days

17.0%

40.2%

0.042

CI of grades III–IV aGvHD at 180 days

3.2%

23.1%

0.025

CI of cGVHD at 1 year

42.7%

57.7%

0.190

CI of moderate to severe cGVHD at 1 year

11.2%

40.1%

0.029

Viral infection

CMV viremia

13 (41.9%)

23 (63.8%)

0.072

  CMV disease

5 (16.1%)

5 (13.9%)

1.000

  EB viremia

14 (45.2%)

24 (66.7%)

0.076

PTLD EBV related

0 (0.0%)

1 (2.8%)

1.000

CIR at 1 year

22.9%

8.7%

0.042

NRM at 1 year

12.9%

36.2%

0.038

Causes of NRM

 GvHD

0 (0%)

7 (23.3%)

0.028

 Infection

0 (0%)

5 (13.9%)

0.091

 MOF

1 (3.2%)

1 (2.8%)

1.000

 Graft failure/dysfunction

3 (9.7%)

1 (2.8%)

0.502

Early mortality (Within 3 months post transplant)

3 (9.7%)

11 (30.6%)

0.036

OS (1 year)

74.9%

59.4%

0.255

LFS (1 year)

64.2%

55.0%

0.400

  1. CMV cytomegalovirus, PTLD posttransplant lymphoproliferative disorder, CIR cumulative incidence of relapse, CI cumulative incidence, NRM non-relapse mortality, MOF multiple organ failure, OS overall survival, LFS leukemia-free survival.