Table 2 Results of multi-level analysis of pH, flow rate, total IgA, HNP1 and lactoferrin concentration.

From: Significant salivary changes in relation to oral mucositis following autologous hematopoietic stem cell transplantation

 

UWS

SWS

 

Effect

95% CI

p

Effect

95% CI

p

pH (ASCT period)

      

   Intercept

5.90

[5.83, 5.98]

<0.001

6.27

[6.11, 6.42]

<0.001

   OMa (yes = 1, no = 0)

−0.02

[−0.14, 0.11]

0.806

0.10

[−0.15, 0.35]

0.429

   Timeb (base = 0, 0–18 = 1)

−0.01

[−0.01, −0.004]

<0.001

−0.01

[−0.02, −0.01]

<0.001

pH (base/12 M)

      

   Intercept

6.20

[6.09, 6.32]

<0.001

6.94

[6.78, 7.10]

<0.001

   OMa (yes = 1, no = 0)

0.02

[−0.13, 0.18]

0.768

0.26

[0.02, 0.49]

0.032

   Timeb (base = 0, 12 M = 1)

−0.01

[−0.13, 0.11]

0.824

−0.21

[−0.38, −0.04]

0.013

Flow rate (ASCT period)

      

   Intercept

0.23

[0.17, 0.28]

<0.001

0.63

[0.47, 0.78]

<0.001

   OMa (yes = 1, no = 0)

−0.06

[−0.15, 0.04]

0.250

0.03

[−0.23, 0.29]

0.830

   Timeb (base = 0, 0–18 = 1)

−0.001

[−0.002, 0.000]

0.257

−0.008

[−0.01, −0.004]

<0.001

Flow rate (base/12 M)

      

   Intercept

0.29

[0.21, 0.37]

<0.001

1.03

[0.80, 1.26]

<0.001

   OMa (yes = 1, no = 0)

−0.08

[−0.21, 0.05]

0.242

0.29

[−0.09, 0.66]

0.137

   Timeb (base = 0, 12 M = 1)

0.01

[−0.06, 0.07]

0.784

−0.09

[−0.26, 0.08]

0.304

Total IgAc (ASCT period)

      

   Intercept

4.03

[3.56, 4.50]

<0.001

3.61

[3.12, 4.09]

<0.001

   OMa (yes = 1, no = 0)

0.06

[−0.64, 0.76]

0.865

0.04

[−0.70, 0.78]

0.913

   Timeb (−4–5 = 0, 6–18 = 1)

−0.52

[−0.92, −0.12]

0.011

−0.76

[−1.09, −0.41]

<0.001

Total IgAc (base/12 M)

      

   Intercept

5.45

[5.03, 5.86]

<0.001

4.81

[4.40, 5.22]

<0.001

   OMa (yes = 1, no = 0)

−0.07

[−0.65, 0.51]

0.815

−0.23

[−0.83, 0.36]

0.435

   Time (base = 0, 12 M = 1)

0.89

[0.49, 1.29]

<0.001

1.08

[0.72, 1.45]

<0.001

HNP1c, d

      

   Intercept

−0.36

[−1.41, 0.68]e

0.496

0.12

[−0.78, 0.91]e

0.748

   OMa (yes = 1, no = 0)

0.05

[−1.42, 1.68]e

0.974

0.49

[−0.63, 1.78]e

0.430

   Timeb (−4–5 = 0, 6–18 = 1)

−3.42

[−5.08, −1.91]e

<0.001

−3.09

[−4.40, −1.76]e

<0.001

Lactoferrinc

      

   Intercept

1.14

[−0.48, 2.75]

0.167

0.16

[−0.94, 1.26]

<0.001

   OMa (yes = 1, no = 0)

−0.37

[−2.46, 1.71]

0.727

0.90

[−0.55, 2.35]

0.224

   Timeb (base = 0, 1–18 = 1)

2.01

[0.36, 3.58]

0.016

1.14

[1.14, 3.29]

<0.001

  1. Bold: significant differences over time.
  2. UWS unstimulated whole-mouth saliva, SWS stimulated whole-mouth saliva, HNP1 neutrophil defensin-1.
  3. aOral mucositis group.
  4. bTime in days.
  5. cLog transformed.
  6. dTobit analysis.
  7. eBootstrap analysis.
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