Table 3 Summary of cumulative incidence of acute and chronic GvHD.

From: Treosulfan–fludarabine–thiotepa-based conditioning treatment before allogeneic hematopoietic stem cell transplantation for pediatric patients with hematological malignancies

aGvHD

Treosulfan (N = 65)

Grades I–IV

  Subjects with event [n (%)]

29 (44.6%)

  Cumulative incidence of acute GvHD at 100 days (%)

45.3

  90% CI

(35.1, 55.5)

Grades II–IV

  Subjects with event [n (%)]

17 (26.2%)

  Cumulative incidence of acute GvHD at 100 days (%)

26.6

  90% CI

(17.5, 35.6)

Grades III–IV

  Subjects with event [n (%)]

5 (7.7%)

  Cumulative incidence of acute GvHD at 100 days (%)

7.8

  90% CI

(2.3, 13.3)

Overall

  Subjects with event [n (%)]

16 (25.8%)

  Cumulative incidence of cGvHD at 36 months (%)

25.8

  90% CI

(16.7, 34.9)

Moderate/severe

  Subjects with event [n (%)]

12 (19.4%)

  Cumulative incidence of cGvHD at 36 months (%)

19.4

  90% CI

(11.1, 27.7)

  1. CI confidence interval, aGvHD acute graft-vs.-host disease, cGvHD chronic graft-vs.-host disease, N number of subjects, n number of subjects in category.