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Umbilical cord blood transplants facilitated by the French cord blood banks network. On behalf of the Agency of Biomedicine, Eurocord and the French society of bone marrow transplant and cell therapy (SFGM-TC)

Bone Marrow Transplantation volume 56, pages 2497–2509 (2021)Cite this article

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Abstract

The public French Cord Blood Banks Network was established in 1999 with the objective of standardizing the practices governing umbilical cord blood (UCB) banking in France. The Network adopted a strategy to optimize its inventory and improve the quality of its banked units based on a quality improvement process using outcome data regularly provided by Eurocord. This study aimed to describe the results, over 10 years, of UCBT facilitated by a national network that used the same criteria of UCB collection and banking and to assess how modifications of banking criteria and unit selection might influence transplant outcomes. Nine hundred and ninety-nine units (593 single-unit and 203 double-unit grafts) were released by the Network to transplant 796 patients with malignant (83%) and non-malignant (17%) diseases. Median cell dose exceeded 3.5 × 107 TNC/kg in 86%. There was a trend to select units more recently collected and with higher cell dose. Neutrophil engraftment was 88.2% (85.7–90.7) and 79.3% (72.6–86.5) respectively for malignant and non-malignant diseases with a trend to faster recovery with higher cell doses. The respective 3-year transplant-related mortality were 31.1% (27.5–35.1) and 34.3% (27.0–43.5). OS was 49% ± 4 in malignant and 62% ± 4 in non-malignant disorders. In multivariate analysis, cell dose was the only unit-related factor associated with outcomes. Our results reflect the benefit on clinical outcomes of the strategy adopted by the Network to bank units with higher cell counts.

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Fig. 1: The Network inventory (2008–2017).
Fig. 2: Percentage of UCB units released yearly.
Fig. 3: Probabilities of 3-year overall survival by transplant period.

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Acknowledgements

We would like to thank Dr. Sergi Querol for his assistance in accessing data from the Antony Nolan and REDMO registries and to acknowledge the work of Ms Cristina Fusté (Data manager at REDMO, Spanish Bone Marrow Registry), and Mr Mahamadou Sinayako (Biostatistician at the ABM, SYRENAD Registry) who have provided the data.

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Authors and Affiliations

  1. Eurocord, Hopital Saint-Louis, AP-HP, Institut de Recherche de Saint-Louis (IRSL) EA3518, Université de Paris, Paris, France

    Hanadi Rafii, Annalisa Ruggeri, Chantal Kenzey, Fernanda Volt, Vanderson Rocha & Eliane Gluckman

  2. Monacord, Centre Scientifique de Monaco, Monaco, Monaco

    Hanadi Rafii, Chantal Kenzey, Fernanda Volt & Eliane Gluckman

  3. Agency of Biomedecine, Saint Denis La Plaine, France

    Federico Garnier, Irina Ionescu, Catherine Faucher & Evelyne Marry

  4. Haematology and Bone Marrow Transplant Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

    Annalisa Ruggeri

  5. Cell Therapy unit, Etablissement Français du Sang Hauts de France Normandie, site de LILLE – Belfort, Lille, France

    Caroline Ballot

  6. Tissue Engineering and Cell Therapy unit, Regional University hospital, Nancy, France

    Danièle Bensoussan

  7. Paoli-Calmettes Institute, Departement of Cancer Biology, Inserm CBT1409, Marseille, France

    Christian Chabannon

  8. Cell Therapy unit, Etablissement Français du Sang, Bordeaux, France

    Bernard Dazey

  9. Cell Therapy unit, University hospital, Montpellier, France

    John De Vos

  10. Cell Therapy unit, Etablissement Français du Sang, Créteil, France

    Eric Gautier

  11. Department of Hematology and Cell Therapy, Etablissement Français du Sang, University hospital, Poitiers, France

    Christine Giraud

  12. Cell Therapy Unit and Cord Blood Bank, AP-HP, Hôpital Saint Louis, Paris, France

    Jérome Larghero & Audrey Cras

  13. Cell Therapy unit, Etablissement Français du Sang, hopital E. Herriot, Lyon, France

    Valérie Mialou

  14. Cell Therapy and Tissue Engineering unit, Etablissement Français du Sang, Grenoble, France

    Virginie Persoons

  15. Cell and Tissue Engineering unit, Etablissement Francais du Sang, Besançon, France

    Fabienne Pouthier

  16. Cell Therapy unit, Etablissement Français du Sang, Rennes, France

    Jean-Baptiste Thibert

  17. Hopital Robert Debré, Assistance Publique - Hôpitaux de Paris, Paris, France

    Jean-Hugues Dalle

  18. Aix-Marseille University and La Timone Children’s Hospital, Marseille, France

    Gerard Michel

  19. Department of Hematology, Clinics Hospital, University of São Paulo Medical School, São Paulo, Brazil

    Vanderson Rocha

  20. Department of Hematology and Stem Cell Transplantation, Clermont University, Clermont-Ferrand, France

    Jacques-Olivier Bay

  21. Department of Hematology and Stem Cell Transplantation, regional university hospital, Nancy, France

    Marie-Thérèse Rubio

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  1. Hanadi Rafii
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  2. Federico Garnier
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Correspondence to Hanadi Rafii.

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Rafii, H., Garnier, F., Ruggeri, A. et al. Umbilical cord blood transplants facilitated by the French cord blood banks network. On behalf of the Agency of Biomedicine, Eurocord and the French society of bone marrow transplant and cell therapy (SFGM-TC). Bone Marrow Transplant 56, 2497–2509 (2021). https://doi.org/10.1038/s41409-021-01313-x

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