Table 2 Busulfan dosing scheme for protocol A and C.

From: EBMT/ESID inborn errors working party guidelines for hematopoietic stem cell transplantation for inborn errors of immunity

Body weight (kg)

Dose (mg/kg)a 4 daysb

Once daily (3 h-infusion)

 3–15

5.1

 15–20

4.9

 25–50

4.1

 50–75

3.3

 75–100

2.7

Twice daily (3 h-infusion)

 3–15

2.5

 15–20

2.4

 25–50

2.1

 50–75

1.6

 75–100

1.3

Four times daily (2 h-infusion)

 3–15

1.3

 15–20

1.2

 25–50

1.0

 50–75

0.8

 75–100

0.7

  1. aTDM doses of Bu are given at same rate (in mg/h) as initial dose, so may not be over 3 h.
  2. For full myeloablative dose (i.e., protocol A) aim for a cumulative Busulfan dose of:
  3. AUC 85–95 mg/L × h (target 90) = 85,000–95,000 ng/ml × h = 20,706–23,180 mmol min
  4. For reduced intensity myeloablative dose (i.e., protocol C) aim for a cumulative Busulfan dose of:
  5. AUC 60–70 mg/L × h (target 65) = 60,000–70,000 ng/ml × h = 14,616–17,052 mmol min
  6. bThe full myeloablative dose (protocol A) is given in 4 days, whereas the reduced intensity myeloablative dose (protocol C) may be administered in 3–4 days (see also Appendix).
Back to article page