Table 4 Donor-and genotype-related conditioning regimens in SCID.

From: EBMT/ESID inborn errors working party guidelines for hematopoietic stem cell transplantation for inborn errors of immunity

 

MSD/MRDc

MUD/MMUD/MMFDc

JAK3, IL2Rγ (T-B+NK-)

Noa/C/D

C/D

RAG1/2, DCLRE1Cb (T-B-NK+)

C/D

C/D

IL7Rα, CD3 δ,ε,ζ, CD45 (T-, B+, NK+)

Noa/C/D

C/D

ADA

Noa/C/D

C/D

AK2

C/D

C/D

  1. aNo: no conditioning.
  2. bSee specific comments on DCLRE1C in the text.
  3. cMSD: matched sibling donor, MRD: matched related donor, MUD: matched unrelated donor, MMUD: mismatched unrelated, MMFD: mismatched family donor.
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