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Hematopoietic stem cell transplantation and cellular therapies for autoimmune diseases (Taylor & Francis eBooks, ISBN 9781138558557, 2021, 686 Pages; Richard Burt, Dominique Farge, Riccardo Saccardi, Milton Ruiz and John Snowden, editors)

Bone Marrow Transplantation volume 57, pages 703–704 (2022)Cite this article

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Over the past 25 years, the utilization of hematopoietic stem cell transplantation (HSCT) specifically for the treatment of autoimmune diseases has gradually evolved from an initial state of ‘salvage therapy’ for severely affected patients towards a ‘standard procedure’ for selected patients in the major indications multiple sclerosis (MS) and systemic sclerosis (SSc). The recently published book entitled ‘Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases’ now summarizes all recent developments and achievements in the area and provides the evidence and state-of-the-art of HSCT and emerging cellular therapies. The selected topics comprehensively highlight all relevant aspects of the procedures. The book was developed under the direction of Richard Burt from the Northwestern University, Chicago, one of pioneers and most eminent leaders in the field, in collaboration with the co-editors Dominique Farge, Milton A Ruiz, Riccardo Saccardi and John A Snowden. The book will attract a broad readership, particularly clinical scientists, clinicians and fellows dedicated to HSCT, both from a hematologic or autoimmune disease perspective.

The first part of the book is devoted to the pathophysiology of ADs, and the scientific rationale and general concepts of the different cellular therapies, including HSCT, while the second part explores in detail the indications and results of these treatments for each disease. Initially, a comprehensive coverage of the immunopathology of autoimmune diseases and biology of stem cells is provided, including preclinical research and the potential mode of action underlying HSCT and cellular-based strategies in this context. A major part of the book also focuses on different types of stem cells and immune cells, principles of cell regulation, microbiome profile and post-transplant immune reconstitution.

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This comment is a book review for the textbook ‘Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases’ (Taylor & Francis eBooks, ISBN 9781138558557, 2021, 686 Pages; Richard Burt, Dominique Farge, Riccardo Saccardi, Milton Ruiz and John Snowden, editors).

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Authors and Affiliations

  1. Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Rheumatology and Clinical Immunology, Berlin, Germany

    Tobias Alexander

  2. Unit of Hematology and Bone Marrow Transplantation, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy

    Raffaella Greco

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  1. Tobias Alexander
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  2. Raffaella Greco
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on behalf of the European Society for Blood and Marrow Transplantation (EBMT) Autoimmune Diseases Working Party (ADWP)

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RG and TA were involved in writing the comment, revising it critically, and approval of the submitted and final versions. The authors contribute this comment on behalf of Autoimmune Diseases Working Party (ADWP) of the European Society for Blood and Marrow Transplantation (EBMT) (https://www.ebmt.org/working-parties/autoimmune-diseases-working-party-adwp).

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Correspondence to Raffaella Greco.

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Competing interests

RG discloses speaking honoraria from educational events supported by Biotest, Pfizer, Medac and Magenta. TA declares speaking honoraria from Amgen, Roche, Pfizer, travel grants from Neovii, and study support from Amgen, Janssen-Cilag and Miltenyi Biotec.

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Alexander, T., Greco, R. & on behalf of the European Society for Blood and Marrow Transplantation (EBMT) Autoimmune Diseases Working Party (ADWP). Hematopoietic stem cell transplantation and cellular therapies for autoimmune diseases (Taylor & Francis eBooks, ISBN 9781138558557, 2021, 686 Pages; Richard Burt, Dominique Farge, Riccardo Saccardi, Milton Ruiz and John Snowden, editors). Bone Marrow Transplant 57, 703–704 (2022). https://doi.org/10.1038/s41409-022-01637-2

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