Table 2 Univariate and multivariate analysis for vaccine failure.

	Student’s t test		Univariate analysis		Multivariate analysis
Parameter	Mean difference (±SD)	P	OR (95% CI)	P	OR (95% CI)	P
aGVHD grade ≥II within 3 months prior to vaccination			9.00 (0.89–90.84)	0.06
Infections during follow-up
Respiratory viruses			2.84 (1.01–7.98)	0.04
Viral reactivations during follow-up			3.34 (1.13–9.86)	0.02	6.53 (1.22–34.95)	0.03
Epstein-Barr virus			2.68 (1.06–6.82)	0.04
Total number of infections and reactivations	−0.85 (±0.43)	0.05
Total of infections and reactivations >4			3.20 (0.93–11.04)	0.08
Usage of relevant immunosuppressive drugs
Steroids			4.74 (1.46–15.44)	0.01
Rituximab			14.39 (0.67–310.25)	0.09
Cell counts at first vaccination
B-cells <135 per mm³	180.23 (±64.68)	0.01	11.33 (3.64–35.34)	0.00	7.24 (1.89–27.68)	0.00
NK-cells <170 per mm³	120.49 (±42.88)	0.01	7.89 (2.65–23.53)	0.00	11.06 (2.39–51.07)	0.00

Parameters investigated in univariate analysis included patient characteristics (age at hematopoietic stem cell transplantation (HSCT), sex, hematological diagnosis), data on HSCT (donor type, cell source, conditioning, anti-thymocyte globuline (ATG), total body irradiation (TBI), T-cell depletion), data on follow-up period (acute graft-versus-host disease (aGVHD), infections and reactivations, usage of relevant immunosuppressive drugs), data on vaccination (time between HSCT and first vaccination, cell counts at the moment of vaccination). P < 0.10 in univariate analysis were included in multivariate logistic regression analysis. Hosmer and Lemeshow test P = 0.966 for this multivariate model. *This OR was calculated by using the Haldane-Anscombe correction.

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