Table 1 Patient characteristics.

From: A gemcitabine-based regimen followed by autologous stem cell transplantation show high efficacy and well tolerance in malignant lymphoma

Characteristics

Number of patients (%)

 

Total (91)

GBC (71)

GBM (20)

Age in years (median, range)

39 (18–64)

38 (18–64)

45 (18–57)

 <60

88 (96.7)

68 (95.8)

20 (100)

 ≥60

3 (3.3)

3 (4.2)

0

Sex

  Male

51 (56.0)

39 (54.9)

12 (60.0)

  Female

40 (44.0)

32 (45.1)

8 (40.0)

ECOG

  0–1

73(80.2)

54 (76.1)

20 (100)

  >2

18 (19.8)

17 (23.9)

0 (0)

Histology

  LBCL

42 (46.2)

33 (46.5)

9 (45.0)

  MCL

16 (17.6)

9 (12.7)

7 (35.0)

  HL

12 (13.2)

9 (12.7)

3 (15.0)

  FL

6 (6.6)

6 (8.4)

0

  Burkitt lymphoma

2 (2.2)

2 (2.8)

0

  PTCL or NK/T lymphoma

12 (13.1)

11 (15.5)

1 (5.0)

  Plasmablastic lymphoma

1 (1.1)

1 (1.4)

0

IPI risk group of LBCL

  Low (0–1)

15 (35.7)

13 (39.4)

2 (22.2)

  Low–Intermediate (2)

10 (23.8)

6 (18.2)

4 (44.4)

  High-Intermediate (3)

13 (31.0)

10 (30.3)

3 (33.4)

  High (4–5)

4 (9.5)

4 (12.1)

0

Ann Arbor stage

  I

4 (4.4)

4 (5.6)

0

  II

13 (14.3)

10 (14.1)

3 (15.0)

  III

25 (27.5)

20 (28.2)

5 (25.0)

  IV

49 (53.8)

37 (52.1)

12 (60.0)

 Bone marrow involvement

32 (35.2)

26 (36.6)

6 (30.0)

 Extra-nodal involvement

47 (51.6)

35 (49.3)

12 (60.0)

 B symptoms

23 (25.3)

18 (25.4)

5 (25.0)

 TP53 or deletion

15 (16.5)

13 (18.3)

2 (10.0)

Number of prior chemotherapies

  1

64 (70.3)

53 (74.6)

11 (55.0)

  ≥2

27 (29.7)

18 (25.4)

9 (45.0)

Status before ASCT

  CR

76 (83.5)

60 (84.5)

16 (80.0)

  CR1

55 (60.4)

47 (66.2)

8 (40.0)

  Not in CR1

21 (23.1)

13 (18.3)

8 (40.0)

  PR

14 (15.4)

10 (14.1)

4 (20.0)

  PR1

9 (9.9)

6 (8.5)

3 (15.0)

  Not in PR1

5 (5.5)

4 (5.6)

1 (5.0)

  SD2

1 (1.1)

1 (1.4)

0

  1. GBC gemcitabine, busulfan, cyclophosphamide, GBM gemcitabine, busulfan, melphalan, ECOG Eastern Cooperative Oncology Group, LBCL large B-cell lymphoma, MCL mantle cell lymphoma, HL Hodgkin’s lymphoma, FL follicular lymphoma, PTCL peripheral T-cell lymphoma, IPI international prognostic index, LDH lactate dehydrogenase, HLH hemophagocytic lymphohistiocytosis, ASCT autologous stem cell transplantation, CR complete remission, CR1 complete remission in first-line treatment, PR partial remission, PR1 partial remission in first-line treatment, SD2 stable disease in second-line treatment.