Table 2 Univariate analysis: OS, Relapse, NRM.

From: Impact of donor age and relationship on outcomes of peripheral blood haploidentical hematopoietic cell transplantation

Variable

OS

Relapse

NRM

 

HR (95% CI)

P

HR (95% CI)

P

HR (95% CI)

P

Donor age

Age <30

–

 

–

 

–

 

Age 30–44

1.25 (0.87–1.82)

0.230

0.64 (0.41–0.98)

0.044

1.93 (1.07–3.47)

0.028

Age >44

1.36 (0.95–1.95)

0.098

0.73 (0.47–1.12)

0.149

1.93 (1.08–3.43)

0.025

Donor sex

M

1.27 (0.95–1.71)

0.108

1.09 (0.75–0.60)

0.639

1.17 (0.77–1.77)

0.463

F

–

 

–

 

–

 

Donor relationship

Child

–

 

–

   

Sibling

0.84 (0.62–1.14)

0.270

0.89 (0.59–1.35)

0.592

0.92 (0.60–40)

0.686

Parent

0.58 (0.35–0.96)

0.033

1.06 (0.61–1.85)

0.826

0.60 (0.28–1.28)

0.188

Other

0.83 (0.44–1.54)

0.544

1.44 (0.75–2.77)

0.279

0.64 (0.22–1.86)

0.415

CMV

D+/R+

–

 

–

 

–

 

D+/R-

0.93 (0.59–1.48)

0.771

1.50 (0.85–2.67)

0.165

0.64 (0.30–1.37)

0.251

D-/R+

0.96 (0.67–1.36)

0.810

0.94 (0.58–1.53)

0.815

1.13 (0.70–1.81)

0.614

D-/R-

0.72 (0.49–1.05)

0.083

1.10 (0.69–1.75)

0.689

0.80 (0.47–1.36)

0.404

HLA§ match

5/10

–

 

–

 

–

 

>5/10

0.86 (0.65–1.15)

0.315

1.26 (0.88–1.80)

0.216

0.65 (0.42–0.99)

0.049

HLA§ DRB1

Match

1.13 (0.74–1.74)

0.567

1.09 (0.62–1.92)

0.765

1.01 (0.53–1.90)

0.990

Mismatch

–

     

Patient age

<46

–

 

–

 

–

 

46–65

1.42 (1.02–.97)

0.038

0.68 (0.456–1.01)

0.056

1.93 (1.16–3.21)

0.011

>65

2.42 (1.64–3.55)

<0.001

1.07 (0.65–1.74)

0.801

2.30 (1.28–4.11)

0.005

Diagnosis*

AML

–

     

ALL

0.87 (0.56–1.34)

0.516

0.82 (0.47–1.42)

0.473

0.98 (0.52–1.83)

0.947

MDS/MPN

1.16 (0.78–1.74)

0.469

0.62 (0.34–1.15)

0.130

1.90 (1.16–3.10)

0.005

Other

0.98 (0.58–1.65)

0.939

1.88 (1.08–3.27)

0.025

0.72 (0.32–1.61)

0.419

DRI

Low

–

 

–

 

–

 

Intermediate

2.26 (1.20–4.26)

0.011

1.55 (0.71–3.38)

0.273

1.60 (0.78–3.29)

0.203

High/very High

3.34 (1.80–6.21)

<0.001

2.93 (1.38–6.23)

0.005

1.52 (0.74–3.13)

0.257

HCI CI**

<3

–

 

–

 

–

 

3 or greater

1.67 (1.19–2.35)

0.003

0.77 (0.53–1.14)

0.194

2.98 (1.62–5.47)

<0.001

KPS***

<80

–

 

–

 

–

 

80 or greater

0.56 (0.39–0.80)

0.001

1.27 (0.75–2.15)

0.367

0.51 (0.31–0.82)

0.006

Disease status

Active

–

 

–

 

–

 

Remission

0.51 (0.39-–0.68)

<0.001

0.42 (0.29–0.60)

<0.001

1.001 (0.67–1.51)

0.996

Conditioning

Myeloablative

0.66 (0.50–0.87)

0.004

0.62 (0.43–0.89)

0.009

0.93 (0.63–1.38)

0.730

Non-myeloablative

–

 

–

 

–

 
  1. *AML Acute myeloid leukemia, ALL acute lymphoblastic leukemia, MDS myelodysplastic syndrome, MPN myeloproliferative neoplasm. Other denotes a heterogenous group of transplantable hematologic malignancies not classified elsewhere.
  2. **The hematopoetic cell transplant comorbidity score (HCT CI) is a comorbidity index that comprises 17 different categories of organ dysfunction. Higher scores represent more comorbidity.
  3. ***Karnofsky performance status (KPS) is a scale ranging from 0 to 100 with higher scores representing greater functional capacity.
  4. ¶Cytomegalovirus (CMV).
  5. §Human leukocyte antigen (HLA).
  6. Bold values represent variables that reached statistical significance.
Back to article page