Table 3 Multivariate analysis.
Variable | OS | Relapse | NRM | |||
|---|---|---|---|---|---|---|
HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | |
Donor age | ||||||
Age <30 | – | – | – | |||
Age 30–44 | 1.16 (0.78–1.71) | 0.463 | 0.61 (0.39–0.96) | 0.034 | 1.65 (0.89–3.05) | 0.110 |
Age >44 | 1.34 (0.92–1.95) | 0.134 | 0.71 (0.46–1.11) | 0.132 | 1.80 (0.98–3.28) | 0.056 |
HLA§ match | ||||||
5/10 | – | – | – | |||
>5/10 | – | – | 0.70 (0.45–1.09) | 0.114 | ||
Patient age | ||||||
Age <46 | – | – | ||||
Age 46–65 | 1.37 (0.97–1.93) | 0.073 | 0.68 (0.46–1.02) | 0.066 | 1.67 (0.94–2.94) | 0.079 |
Age >65 | 2.09 (1.37–3.20) | <0.001 | 1.05 (0.61–1.82) | 0.857 | 1.69 (0.87–3.25) | 0.119 |
DRI | ||||||
Low | – | – | – | |||
Intermediate | 2.19 (1.16–4,14) | 0.015 | 1.49 (0.68–3.26) | 0.315 | – | |
High/Very high | 2.23 (1.13–4.40) | 0.021 | 1.86 (0.82–4.26) | 0.140 | – | |
HCT CI** | ||||||
<3 | – | – | – | |||
3 or greater | 1.39 (0.98-1.96) | 0.064 | – | 2.64 (1.43-4.90) | 0.002 | |
Conditioning | ||||||
Myeloablative | 0.82 (0.61-1.10) | 0.189 | 0.53 (0.36-0.77) | <0.001 | – | |
Non-myeloablative | – | – | – | |||
KPS*** | ||||||
<80 | – | – | – | |||
80 or greater | 0.56 (0.39-0.80) | 0.002 | – | 0.54 (0.33-0.88) | 0.014 | |
Disease status | ||||||
Active | – | – | ||||
Remission | 0.55 (0.37-0.80) | 0.002 | 0.47 (0.28-0.77) | 0.003 | ||
Diagnosis* | ||||||
AML | – | – | – | |||
ALL | – | – | 1.36 (0.70-2.65) | 0.368 | ||
MDS/MPN | – | – | 1.73 (1.05-2.85) | 0.030 | ||
Other | – | – | 0.87 (0.42-1.80) | 0.702 | ||
