Fig. 3: Platelet and RBC transfusion rate per month over time, patient level presentation.

The color of a rectangle for a patient in a specific month indicates the number of units of platelets (left) or RBC (right) that the patient had received during that month. Blue indicates a small number of units or none, while red indicates more than six units. For presentation purposes, patients receiving more than six transfusion units per month, were fixed to six units. Grey rectangles indicate patients who discontinued follow up, horizontal grey lines indicate patients who died. Month “-1” presents a mean monthly value prior to study drug administration (the number of units for the 3 months preceding baseline were summed and divided by 3). From month 1 onward, the value represents the number of units for a specific month for that patient. The letters represent hematopoietic growth factor use: T = TPO receptor agonists, G = colony stimulating factors (G-CSF, GM-CSF), E = recombinant erythropoietin.