Table 2 Multivariate Cox regression analysis of risk factors for overall survival (OS), relapse-free survival (RFS), non-relapse mortality (NRM) and relapse incidence (RI).
Variable | OS | RFS | RI | NRM | ||||
|---|---|---|---|---|---|---|---|---|
HR (95% CI) | p-Value | HR (95% CI) | p-Value | HR (95% CI) | p-Value | HR (95% CI) | p-Value | |
RIC | 0.64 (0.35–1.18) | 0.15 | 0.93 (0.53–1.63) | 0.80 | 1.48 (0.69–3.21) | 0.32 | 0.74 (0.35–1.56) | 0.42 |
Low cytogenetic risk | 1.80 (0.80–4.02) | 0.15 | 1.58 (0.74–3.35) | 0.23 | 0.58 (0.21–1.61) | 0.3 | 4.14 (1.20–14.29) | 0.02 |
High cytogenetic risk | 1.81 (0.82–3.99) | 0.14 | 1.93 (0.92–4.04) | 0.08 | 1.66 (0.69–3.98) | 0.26 | 3.21 (0.87–11.87) | 0.08 |
ECOG > 0 | 2.45 (1.24–4.84) | 0.01 | 2.08 (1.12–3.84) | 0.02 | n.a. | 3.49 (1.33–9.16) | 0.01 | |
Chemotherapy pre HCT | 2.31 (1.26–4.24) | 0.01 | 2.00 (1.14–3.49) | 0.01 | 3.02 (1.37–6.64) | 0.006 | ||
Subgroup analysis | ||||||||
Low cytogenetic risk: RIC | 0.22 (0.09–0.57) | 0.002 | 0.37 (0.16–0.86) | 0.02 | 0.29 (0.1–0.79) | 0.02 | ||
Intermediated cytogenetic risk: RIC | 0.9 (0.25–3.23) | 0.88 | 1.34 (0.4–4.44) | 0.63 | 2.49 (0.23–27.52) | 0.46 | ||
High cytogenetic risk: RIC | 1.7 (0.64–4.51) | 0.29 | 2.08 (0.84–5.12) | 0.11 | 2.86 (0.71–11.52) | 0.14 | ||
