Table 3 Subdistribution hazard ratios for single lung function parameters after allo-HCT at day 100 for BOS incidence.

From: Evaluation of risk for bronchiolitis obliterans syndrome after allogeneic hematopoietic cell transplantation with myeloablative conditioning regimens

Subsdistribution hazard ratio estimates for BOS incidence of patients surviving at least 100 days with available PFTs (n = 200/245)

Median time from selected PFT parameters d + 100 to BOS (days)

 

Parameter before allo-HCT

Parameter at day 100 after allo-HCT

 

n

p value

SHR

95% CI

n

p value

SHR

95% CI

 

FEV1/FVC < 0.80 ratio

72

0.35

1.31

0.75, 2.30

86

0.08

1.63

0.94, 2.82

268

FEV1/FVC < 0.70 ratio

12

0.11

2.17

0.84, 5.73

18

0.001

3.47

1.68, 7.14

291

FEV1 < median (99% of predicted)

90

0.002

2.54

1.41, 4.58

115

0.001

4.10

2.00, 8.43

164

FEV1 < 75% predicted

8

0.12

2.20

0.82, 5.84

23

0.03

2.25

1.09, 4.66

386

RV > 120% predicted

66

0.37

1.29

0.74, 2.25

63

0.97

0.98

0.54, 1.78

171

RV/TLC > 0.45 ratio

13

0.86

0.90

0.27, 2.97

22

0.02

2.57

1.23, 5.36

182

TLC < 80% predicted

15

0.11

0.21

0.31, 1.41

34

0.14

1.64

0.84, 3.18

329

MEF50 < 50% predicted

30

0.12

1.66

0.87, 3.17

43

0.001

3.17

1.82, 5.51

379

MEF50 < 35% predicted

6

0.67

1.30

0.38, 4.50

14

0.001

5.19

2.58, 10.4

350

MEF25 < 35% predicted

11

0.41

1.48

0.57, 3.84

62

0.001

3.29

1.89, 5.72

393

MEF25 < 25% predicted

6

0.67

1.30

0.38, 4.50

24

0.001

3.42

1.88, 6.23

277

DLCOc SB < 80% predicted

97

0.44

1.28

0.68, 2.39

97

0.12

1.58

0.88, 2.83

271

DLCOc SB < 60% predicted

20

0.50

1.35

0.55, 3.32

20

0.52

1.22

0.66, 2.24

321

  1. Patients surviving 100 days and with available pulmonary function tests were selected for the analysis (200/245, 82%). Subdistribution hazard ratios (SHR) and confidence intervals (CI) for single pulmonary function test (PFT) values at day 100 after allo-HCT were estimated for BOS in univariate analysis using the Fine and Gray regression model in the presence of competing risks. Cut-off values for PFT were chosen from the significant PFT parameters before allo-HCT and previous publications (Duque-Afonso et al. 2018). Only patients surviving 100 days after allo-HCT and with pulmonary function test (PFT) within the first 100 days after allo-HCT were included in this analysis. Median time from selected PFT parameters from d + 100 to BOS was calculated only for patients developing BOS.
  2. BOS bronchiolitis obliterans syndrome, PFT pulmonary function tests, allo-HCT allogenic hematopoietic cell transplantation, FEV1 forced expiratory volume in 1 second (FEV1), FVC forced vital capacity, RV residual volume, TLC total lung capacity, MEF50 mid-expiratory flow 50%, MEF25 mid-expiratory flow 25%, DLCOc SB carbon monoxide diffusion capacity corrected for hemoglobin.
Back to article page