Table 1 Patient Demographics and disease characteristics within study population.

From: Characteristics and outcomes of therapy-related acute leukemia following autologous transplant (Auto-HCT) for multiple myeloma

Characteristic

Value (%)

 

n = 18

Sex

 Male

6 (33%)

 Female

12 (67%)

Race

 White

15 (83%)

 Black

3 (17%)

Age at First Diagnosis (mean ± SD)

62.7 ± 8.4 years

ECOG

 0

6 (33%)

 1

12 (67%)

Myeloma Type

 IgG

15 (83%)

 IgA

3 (17%)

Kappa/Lambda

 Kappa

14 (78%)

 Lambda

4 (22%)

Stage (ISS)

 I

2 (11%)

 II

12 (67%)

 III

4 (22%)

Pre-HCT Exposure

Lenalidomide

18 (100%)

Alkylating Agent

2 (11%)

Topoisomerase

0 (0%)

Leukemia Type

 AML

8 (44%)

 APML

1 (6%)

 B-ALL

9 (50%)

Top Recurrent Mutations

 DNMT3A

6 (33%)

 TP53

5 (28%)

 ETV6

4 (22%)

 RUNX1

4 (22%)

 GATA2

3 (17%)

 NOTCH2

3 (17%)