Table 3 Multivariable Cox PH analysis on OS and EFS, stratified for transplantation regime.

Age

single

1.02

1.01–1.03

0.001**

1

1–1.01

0.26

tandem

1.04

1.02–1.06

<0.001***

1.01

1–1.03

0.03

Body Mass Index

single

0.98

0.98–1.01

0.81

1.01

1–1.02

0.20

tandem

0.97

0.94–1

0.99

0.99

0.97–1.01

0.47

Sex

female

1

1

male

single

1.04

0.89–1.23

0.6

1.09

0.97–1.22

0.15

tandem

0.98

0.73–1.31

0.87

0.94

0.77–1.15

0.54

t(4;14)

no

1

1

yes

single

1.39

0.91–2.12

0.12

1.55

1.16–2.07

0.003**

tandem

2.05

1.1–3.84

0.02*

1.65

1.09–2.5

0.02*

t(14;16)

no

1

1

yes

single

0.68

0.21–2.17

0.51

0.88

0.4–1.96

0.76

tandem

4.22

0.45–39.52

0.21

2.17

0.61–7.69

0.23

del(17p)

no

1

1

yes

single

1.13

0.57–2.23

0.73

1.51

0.94–2.42

0.89

tandem

0.66

0.25–1.69

0.38

0.48

0.23–0.99

0.05*

ampl(1q)

no

1

1

yes

single

0.84

0.54–1.31

0.44

1.02

0.76–1.37

0.9

tandem

1.31

0.71–2.42

0.38

1.22

0.8–1.86

0.35

ISS

I

1

1

II

single

1.52

1.19–1.93

<0.001***

1.31

1.14–1.51

0.004**

tandem

2

1.27–3.16

0.003**

1.44

1.08–1.91

0.01*

III

single

1.86

1.45–2.39

<0.001***

1.26

1.04–1.51

<0.001***

tandem

2.25

1.38–3.66

0.001**

1.87

1.37–2.54

<0.001***

Heavy Chain

IgA

1

1

IgG

single

0.73

0.59–0.9

0.003**

0.76

0.66–0.88

<0.001***

tandem

0.74

0.5–1.08

0.12

0.76

0.58–1

0.05*

Light Chain

Kappa

1

1

Lambda

single

1.07

0.91–1.26

0.41

1.07

0.95–1.2

0.27

tandem

1.25

0.92–1.71

0.16

1.18

0.95–1.47

0.12

Remission after induction therapy

CR

1

1

nonCR

single

1.2

0.91–1.57

0.18

1.26

1.04–1.51

0.02*

tandem

1.45

0.81–2.6

0.22

1.31

0.88–1.95

0.18

Remission after 1st ASCT

CR

1

1

nonCR

single

1.5

1.2–1.86

<0.001***

1.31

1.14–1.51

<0.001***

tandem

1

0.5–2.03

0.99

0.97

0.6–1.55

0.47

Renal Impairment

no

1

1

yes

single

0.87

0.7–1.08

0.21

0.94

0.81–1.09

0.4

tandem

1.36

0.93–2.01

0.12

1.13

0.84–1.52

0.41

Karnofsky

single

0.98

0.97–0.99

<0.001***

0.99

0.99–1

0.008**

tandem

0.9

0.97–1.01

0.22

1

0.99–1.01

0.81

Conditioning Dose

100

1

1

140

single

0.94

0.61–1.45

0.78

0.95

0.7–1.3

0.76

tandem

1.2

0.64–2.24

0.57

1.26

0.82–1.94

0.29

200

single

0.92

0.61–1.39

0.68

0.92

0.68–1.24

0.58

tandem

0.97

0.55–1.72

0.93

0.92

0.62–1.36

0.67

Time Period

1998–2007

1

1

2008–2016

single

0.48

0.32–0.72

<0.001***

0.67

0.47–0.95

0.02*

tandem

0.54

0.34–0.88

0.01*

0.73

0.49–1.08

0.11

2017–2021

single

0.43

0.28–0.65

<0.001***

0.5

0.35–0.71

<0.001***

tandem

0.48

0.28–0.83

0.009**

0.48

0.31–0.72

<0.001***