Table 2 Multivariate analysis of transplant outcomes.

From: Fludarabine melphalan reduced intensity conditioning vs radiation-based myeloablative conditioning in patients undergoing allogeneic transplantation for acute myeloid leukemia with measurable residual disease

 

Overall survival

LFS

  

N

Adjusted HR (95%CI)a

Pa

Adjusted HR (95%CI)a

Pa

Disease status

CR1

263

Reference

0.14

Reference

0.027

CR2

49

1.44 (0.89,2.33)

 

1.63 (1.06,2.52)

 

MRD

MRD−

268

Reference

<0.001

Reference

<0.001

MRD+

44

2.64 (1.68,4.15)

 

2.55 (1.66,3.91)

 
 

Relapse

NRM

  

N

Adjusted HR (95%CI)b

Pb

Adjusted HR (95%CI)b

Pb

Disease status

CR1

263

Reference

0.015

Reference

0.49

CR2

49

2.02 (1.15,3.56)

 

1.26 (0.66,2.41)

 

MRD

MRD−

268

Reference

0.003

Reference

0.23

MRD+

44

2.46 (1.36,4.45)

 

1.54 (0.76,3.11)

 
  1. aBased on multivariable Cox regression model adjusted for age, KPS and MRD to OS, and KPS, disease status, conditioning, and MRD to LFS.
  2. bBased on multivariable Fine and Gray regression model. Disease status, KPS and MRD were adjusted for relapse. Age was adjusted for NRM.
  3. Bold values indicate statistical significance p < 0.05.
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