Table 1 Number of patients receiving a first allogeneic or first autologous HCT in 2023 by indication, donor type, and stem cell source.
Transplant activity 2023 | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of patients | |||||||||||||||||||
Allogeneic | Autologous | T o t a l | |||||||||||||||||
Family | Unrelated | Allo | Auto | Total | |||||||||||||||
HLA-id | Twin | Haplo ≥ 2 MM | Other family | BM | BM + | ||||||||||||||
BM | PBSC | Cord | BM | PBSC | BM | PBSC | BM | PBSC | Cord | BM | PBSC | Cord | only | PBSC | Cord | ||||
Myeloid malignancies | 214 | 2283 | 2 | 2 | 21 | 248 | 1738 | 3 | 71 | 1 | 308 | 6748 | 109 | 0 | 191 | 1 | 11,748 | 192 | 11,940 |
Acute myeloid leukemia | 152 | 1626 | 2 | 1 | 19 | 181 | 1259 | 2 | 44 | 1 | 177 | 4250 | 88 | 0 | 178 | 1 | 7802 | 179 | 7981 |
1st complete remission | 94 | 1055 | 1 | 1 | 19 | 97 | 691 | 1 | 28 | 1 | 96 | 2393 | 45 | 0 | 158 | 0 | 4522 | 158 | 4680 |
Not 1st complete remission | 45 | 336 | 0 | 0 | 0 | 61 | 356 | 1 | 10 | 0 | 56 | 955 | 29 | 0 | 18 | 1 | 1849 | 19 | 1868 |
AML therapy related | 9 | 73 | 0 | 0 | 0 | 5 | 65 | 0 | 1 | 0 | 11 | 239 | 5 | 0 | 1 | 0 | 408 | 1 | 409 |
AML with MDS-related changes | 4 | 162 | 1 | 0 | 0 | 18 | 147 | 0 | 5 | 0 | 14 | 663 | 9 | 0 | 1 | 0 | 1023 | 1 | 1024 |
Chronic myeloid leukemia | 6 | 88 | 0 | 0 | 0 | 8 | 44 | 0 | 5 | 0 | 17 | 193 | 5 | 0 | 5 | 0 | 366 | 5 | 371 |
Chronic phase | 3 | 46 | 0 | 0 | 0 | 4 | 18 | 0 | 2 | 0 | 10 | 93 | 4 | 0 | 5 | 0 | 180 | 5 | 185 |
Not chronic phase | 3 | 42 | 0 | 0 | 0 | 4 | 26 | 0 | 3 | 0 | 7 | 100 | 1 | 0 | 0 | 0 | 186 | 0 | 186 |
MDS or MDS/MPN overlap | 51 | 379 | 0 | 1 | 2 | 53 | 319 | 1 | 18 | 0 | 104 | 1629 | 16 | 0 | 7 | 0 | 2573 | 7 | 2580 |
MPN | 5 | 190 | 0 | 0 | 0 | 6 | 116 | 0 | 4 | 0 | 10 | 676 | 0 | 0 | 1 | 0 | 1007 | 1 | 1008 |
Lymphoid malignancies | 269 | 1111 | 0 | 1 | 11 | 194 | 859 | 7 | 47 | 0 | 226 | 2061 | 64 | 5 | 22,200 | 0 | 4850 | 22,205 | 27,055 |
Acute lymphatic leukemia | 238 | 711 | 0 | 1 | 7 | 149 | 520 | 3 | 22 | 0 | 202 | 1182 | 54 | 0 | 39 | 0 | 3089 | 39 | 3128 |
1st complete remission | 131 | 501 | 0 | 0 | 6 | 81 | 267 | 0 | 14 | 0 | 106 | 799 | 25 | 0 | 36 | 0 | 1930 | 36 | 1966 |
Not 1st complete remission | 107 | 210 | 0 | 1 | 1 | 68 | 253 | 3 | 8 | 0 | 96 | 383 | 29 | 0 | 3 | 0 | 1159 | 3 | 1162 |
Chronic lymphocytic leukemia | 0 | 35 | 0 | 0 | 0 | 1 | 14 | 1 | 1 | 0 | 0 | 122 | 0 | 0 | 5 | 0 | 174 | 5 | 179 |
Plasma cell disorders—MM | 1 | 33 | 0 | 0 | 2 | 2 | 12 | 0 | 9 | 0 | 0 | 99 | 0 | 1 | 13802 | 0 | 158 | 13803 | 13961 |
Plasma cell disorders—other | 3 | 5 | 0 | 0 | 1 | 1 | 2 | 0 | 0 | 0 | 0 | 17 | 1 | 1 | 467 | 0 | 30 | 468 | 498 |
Hodgkin lymphoma | 6 | 87 | 0 | 0 | 0 | 14 | 104 | 2 | 4 | 0 | 3 | 143 | 3 | 1 | 2280 | 0 | 366 | 2281 | 2647 |
DLBCL NHL all types | 2 | 77 | 0 | 0 | 0 | 7 | 57 | 0 | 6 | 0 | 3 | 126 | 1 | 2 | 2836 | 0 | 279 | 2838 | 3117 |
Other B-cell NHL | 2 | 39 | 0 | 0 | 1 | 6 | 34 | 0 | 1 | 0 | 3 | 75 | 0 | 0 | 1988 | 0 | 161 | 1988 | 2149 |
T cell NHL | 17 | 124 | 0 | 0 | 0 | 14 | 116 | 1 | 4 | 0 | 15 | 297 | 5 | 0 | 783 | 0 | 593 | 783 | 1376 |
Solid tumors | 1 | 3 | 0 | 0 | 0 | 2 | 25 | 0 | 1 | 0 | 0 | 6 | 0 | 5 | 1603 | 0 | 38 | 1608 | 1646 |
Neuroblastoma | 1 | 1 | 0 | 0 | 0 | 2 | 23 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 570 | 0 | 28 | 571 | 599 |
Soft tissue sarcoma | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 2 | 58 | 0 | 3 | 60 | 63 |
Ewing sarcoma | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 161 | 0 | 1 | 162 | 163 |
Germinal tumors | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 480 | 0 | 1 | 481 | 482 |
Other solid tumors | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 334 | 0 | 5 | 334 | 339 |
Non-malignant disorders | 638 | 360 | 17 | 4 | 4 | 197 | 200 | 75 | 56 | 0 | 447 | 527 | 33 | 4 | 512 | 1 | 2558 | 517 | 3075 |
Bone marrow failure—SAA | 165 | 135 | 0 | 3 | 4 | 59 | 49 | 8 | 6 | 0 | 150 | 161 | 2 | 1 | 1 | 0 | 742 | 2 | 744 |
Bone marrow failure—other | 71 | 36 | 1 | 0 | 0 | 15 | 17 | 12 | 7 | 0 | 60 | 46 | 3 | 0 | 0 | 0 | 268 | 0 | 268 |
Thalassemia | 98 | 49 | 8 | 1 | 0 | 10 | 8 | 15 | 12 | 0 | 44 | 66 | 0 | 0 | 4 | 0 | 311 | 4 | 315 |
Sickle cell disease | 162 | 91 | 4 | 0 | 0 | 53 | 28 | 20 | 8 | 0 | 15 | 11 | 1 | 1 | 2 | 0 | 393 | 3 | 396 |
Inborn errors of immunity | 106 | 37 | 4 | 0 | 0 | 56 | 80 | 18 | 14 | 0 | 126 | 172 | 11 | 2 | 0 | 0 | 624 | 2 | 626 |
Inborn errors of metabolism | 31 | 8 | 0 | 0 | 0 | 4 | 16 | 2 | 9 | 0 | 50 | 59 | 15 | 0 | 1 | 1 | 194 | 2 | 196 |
Autoimmune disease—MS | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 0 | 0 | 419 | 0 | 8 | 419 | 427 |
Autoimmune disease -SSC | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 51 | 0 | 0 | 51 | 51 |
Autoimmune disease—other | 4 | 2 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 2 | 7 | 1 | 0 | 34 | 0 | 18 | 34 | 52 |
Others | 25 | 29 | 1 | 0 | 0 | 16 | 19 | 5 | 3 | 0 | 26 | 47 | 3 | 0 | 12 | 0 | 174 | 12 | 186 |
Total patients | 1147 | 3786 | 20 | 7 | 36 | 657 | 2841 | 90 | 178 | 1 | 1007 | 9389 | 209 | 14 | 24,518 | 2 | 19,368 | 24,534 | 43,902 |
Re/additional transplants | 28 | 118 | 0 | 0 | 1 | 48 | 328 | 6 | 9 | 0 | 45 | 508 | 26 | 3 | 2709 | 0 | 1117 | 2712 | 3829 |
Total transplants | 1175 | 3904 | 20 | 7 | 37 | 705 | 3169 | 96 | 187 | 1 | 1052 | 9897 | 235 | 17 | 27,227 | 2 | 20,485 | 27,246 | 47,731 |
N. Pediatric patients (<18 at HCT) | 857 | 388 | 17 | 5 | 4 | 351 | 565 | 83 | 66 | 0 | 729 | 917 | 129 | 12 | 1330 | 2 | 4111 | 1344 | 5455 |
