Table 2 Graft contents and engraftment characteristics.

From: αß T-cell depleted haploidentical stem cell transplantation for pediatric and young adult patients with transfusion-dependent thalassemia

Graft content (median)

MSD

T-haplo-HSCT

TCRαβ/CD19

CD3/CD19

CD34+ cells/kg BW

 

15 (9–24) × 106

17 (10–24) ×106

12 (9–22) ×106

TNC/kg BW

5 (3–8) x 108

   

CD3+ T cells/kg BW

  

571 (140–2915) ×104

10 (0.7–42) ×104

TCRαβ/ CD3+ T cells/ kg BW

  

0.4 (0.1–1.6) ×104

 

CD19+ B cells/kg BW

 

4 (0.4–12) ×104

4 (2–11) ×104

3 (0.4–12) ×104

Time to Engraftment (days; median)

Leukocyte >1 ×109 L–1

29 (20–37)

13 (11–36)

14 (11–36)

12 (11–18)

Granulocyte >0.5 ×109 L–1

31 (20–43)

17 (11–35)

17 (11–35)

16 (13–18)

Thrombocyte >20 ×109 L–1

40 (25–406)

15 (12–36)

15 (12–36)

16 (15–17)

  1. Absolute cell doses per kilogram (kg) body weight (BW) and days of engraftment values are shown as median (minimum-maximum values).
  2. T-haplo-HSCT indicates patients who underwent T-haplo-HSCT (both T-cell depletion procedures), CD3/CD19 patients only with CD3/CD19 T-cell depletion, TCRαβ/CD19 patients only with TCRαβ/CD19 T-cell depletion, MSD patients with an HLA identical donor (matched sibling donor).
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