Table 1 Characteristics of patients grouped by transplant strategy given.

From: Outcomes following different upfront stem cell transplantation strategies for multiple myeloma: a statistical perspective on behalf of the Chronic Malignancies Working Party of the EBMT

 

Single auto-HCT

Tandem auto-HCT

Auto-allo-HCT

All cases

Frequency

%

Frequency

%

Frequency

%

Frequency

%

Sex

Male

11,670

57.3%

2215

60.1%

554

63.1%

14,439

57.9%

Female

8705

42.7%

1468

39.9%

324

36.9%

10,497

42.1%

Total

20,375

100.0%

3683

100.0%

878

100.0%

24,936

100.0%

Age at first auto

18–50

3943

19.4%

769

20.9%

369

42.0%

5081

20.4%

50–60

9782

48.0%

1791

48.6%

411

46.8%

11,984

48.1%

60–65

6650

32.6%

1123

30.5%

98

11.2%

7871

31.6%

Total

20,375

100.0%

3683

100.0%

878

100.0%

24,936

100.0%

Median (Q1,Q3)

57.2 (51.7, 61.2)

56.7 (51.2, 60.9)

51.7 (45.5, 56.9)

57.0 (51.4, 61.0)

Year of first auto

2002–2006

5863

28.8%

1826

49.6%

491

55.9%

8180

32.8%

2007–2011

9705

47.6%

1299

35.3%

302

34.4%

11,306

45.3%

2012–2015

4807

23.6%

558

15.2%

85

9.7%

5450

21.9%

Total

20,375

100.0%

3683

100.0%

878

100.0%

24,936

100.0%

Time diag- first auto

<12mo

15,696

77.0%

2983

81.0%

754

85.9%

19,433

77.9%

>=12

4679

23.0%

700

19.0%

124

14.1%

5503

22.1%

Total

20,375

100.0%

3683

100.0%

878

100.0%

24,936

100.0%

Status at first auto

CR

4015

19.7%

339

9.2%

71

8.1%

4425

17.7%

PR

13,923

68.3%

2651

72.0%

590

67.2%

17,164

68.8%

Other/NA

2437

12.0%

693

18.8%

217

24.7%

3347

13.4%

Total

20,375

100.0%

3683

100.0%

878

100.0%

24,936

100.0%

MM classification

Ig G

10,463

52.7%

1909

53.7%

452

52.6%

12,824

52.9%

Ig A

3739

18.8%

571

16.1%

178

20.7%

4488

18.5%

Light chain

4829

24.3%

945

26.6%

192

22.3%

5966

24.6%

Other

820

4.1%

128

3.6%

38

4.4%

986

4.1%

Total

19,851

100.0%

3553

100.0%

860

100.0%

24,264

100.0%

Time diag- first auto

<12mo

15,696

77.0%

2983

81.0%

754

85.9%

19,433

77.9%

>=12

4679

23.0%

700

19.0%

124

14.1%

5503

22.1%

Total

20,375

100.0%

3683

100.0%

878

100.0%

24,936

100.0%

Chain type

Kappa

11,556

64.9%

2145

67.2%

529

65.6%

14,230

65.3%

Lambda

6190

34.8%

1035

32.4%

278

34.4%

7503

34.4%

Both kappa and lambda

50

0.3%

10

0.3%

0

0.0%

60

0.3%

Total

17,796

100.0%

3190

100.0%

807

100.0%

21,793

100.0%

  1. Significance testing for differences between the 3 groups is irrelevant, being warranted by the very large sample size (all P-values < 0.001, not displayed). Auto-allo-HCT were RIC in 85% of the cases; donors were Hla-identical sibling (72%), matched unrelated donor (25%) or other (3%).