Table 2 Histomorphometric Analysis of Bone Parameters in the Femurs of 9-week-old Mice

From: NUMB maintains bone mass by promoting degradation of PTEN and GLI1 via ubiquitination in osteoblasts

Parameter

WT (n = 10)

DKO (n = 10)

P value

(N.Ob/T.Pm)/ (#Ob per mm)

51.54 ± 5.08

26.98 ± 3.82*

<0.001

MAR/(μm·d-1)

4.87 ± 0.38

3.041 ± 0.28*

<0.001

(MS/BS)/%

15.86 ± 1.12

8.17 ± 1.06*

<0.001

(N.Oc/T.Pm)/(#Oc per mm)

4.14±0.53

7.21±0.6*

<0.001

(Oc S/BS)/%

9.73±0.80

15.96±1.17*

<0.001

Oc surface/(μm per Oc)

30.09±2.36

39.54±5.77*

0.001

  1. Histomorphometry was performed on femurs. Values represent the mean ± SD; n = 10
  2. aSignificantly different from WT by unpaired t test, P<0.05 N.Ob/T.Pm: osteoblasts per trabecular bone perimeter;
  3. N.Ob/T.Pm osteoblasts per trabecular bone perimeter, MAR mineral apposition rate, MS/BS mineral surface rate, N.Oc/T. Pm osteoclast number/tissue perimeter ratio, N.Oc/BS osteoclast number/bone surface
  4. *Significantly different from WT by unpaired t test, P < 0.05
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