Fig. 8

The interplay between mesenchymal stem cells and osteoclasts supports calvarial bone tissue homeostasis. 1 Suture MSCs are activated by IHH secreted by osteoprogenitors, which is dependent on BMP signalling. 2 BMP-mediated IHH signalling and RANKL may function synergistically to promote the differentiation and resorption activity of osteoclasts