Fig. 8
From: Advanced smart biomaterials and constructs for hard tissue engineering and regeneration
Smart inhibition of bacteria without inducing drug resistance. a Minimal inhibitory concentration (MIC). Twenty passages were tested, and each passage used the surviving bacteria from the previous passage as inoculum. A twofold increase in MIC occurred for DMADDM and CHX, indicating drug resistance. However, DMAHDM had no drug resistance. b From 1 to 20 passages, S. gordonii biofilm CFU on DMAHDM resin maintained a 4 log reduction over that without DMAHDM, showing the same sensitivity with no drug resistance. In b, bars with dissimilar letters are significantly different from each other (P < 0.05). (Adapted from ref. 146, with permission.)
