Table 1 Bone diseases or dysfunctions caused by glutamate GPCR mutation or deletion
GPCR | Species | Bone diseases or dysfunctions caused by GPCR mutation or deletion | References |
|---|---|---|---|
CASR | Human | Association between A986S polymorphism, reduced BMD, and elevated osteoporosis risk | Lorentzon et al.110 Di et al.20 |
| Â | Mouse | Reduced body length and bone mass | Ho et al.30 Chang et al.88 |
GABABR1 | Mouse | Reduced BMD | Takahata et al.111 |
GPRC6A | Mouse | Reduced BMD, mineralization, and femur width | Pi et al.112 Pi et al.113 |
GRM1 | Mouse | Reduced body length and BMD | Musante et al.114 |
TAS1R3 | Mouse | Reduced bone resorption and increased bone mass | Eaton et al.115 Simon et al.116 |
