Table 4 Bone diseases or dysfunctions caused by the γ-group of rhodopsin GPCR mutation or deletion
GPCR | Species | Bone diseases or dysfunctions caused by GPCR mutation or deletion | References |
|---|---|---|---|
BDKRB1 | Mouse | Reduced bone loss | Gonçalves et al.190 |
CCR1 | Mouse | Reduced bone mass | Hoshino et al.191 |
Taddei et al.192 | |||
CCR2 | Human | CCR2 Val/Ile and CCR2 Val+genotype were associated with osteoporosis | Eraltan et al.185 |
Mouse | Delayed fracture healing | Xing et al.199 | |
Larger and stronger tibial bones | Mader et al.203 | ||
CCR5 | Mouse | Reduced cartilage degeneration postsurgery | Takebe et al.204 |
Promoted alveolar bone resorption | Andrade et al.205 | ||
CCR6 | Mouse | Reduced bone mass | Doucet et al.193 |
CCR7 | Mouse | Reduced functional deficits and subchondral bone changes in the DMM model | Sambamurthy et al.206 |
CMKLR1 | Mouse | Reduced bone mass and BMD in male | Zhao et al.194 |
CX3CR1 | Mouse | Increased bone mass | Hoshino et al.189 |
CXCR2 | Mouse | Reduced body length, bone mass, and BMD | Bischoff et al.36 |
Reduced arthritis severity | Jacobs et al.201 | ||
CXCR4 | Mouse | Reduced femoral length and bone mass | Zhu et al.195 |
Reduced bone fracture healing | Kawakami et al.200 | ||
GPR1 | Mouse | Reduced BMD and bone mass | Liet al et al.196 |
GPR142 | Mouse | Reduced CAIA-induced arthritis severity | Murakoshi et al.202 |
GPR54 | Mouse | Reduced bone mass | Brommage et al.197 |
MCHR1 | Mouse | Induced osteoporosis | Bohlooly et al.198 |
OPRM1 | Human | rs9479769, rs4870268, and rs1998221 SNPs were associated with reduced BMD and bone mass | Lu et al.29 |
