Table 7 Diseases or dysfunctions caused by Frizzled/Taste2 GPCR mutation or deletion

Frizzled-1

Human

rs2232157 and rs2232158 SNPs were associated with reduced BMD

Zhang et al.²⁸²

Yerges et al.²⁸³

Frizzled-6

Human

Two mutations (c.1750G>T and c.1531C>T) caused nail dysplasia

Frojmark et al.²⁸⁴

Wilson et al.²⁸⁵

Naz et al.²⁸⁶

Mouse

50% of male mice displayed abnormal claw morphology or lack of claws

Frojmark et al.²⁸⁴

Frizzled-9

Human

The mutation was associated with reduced BMD

Francke et al.²⁸⁷

Wang et al.²⁷³

Heilmann et al.²⁸⁹

Mouse

Induced osteopenia and reduced formation of new bone after fractures

Albers et al.²⁸⁸

SMOH

Mouse

Reduced BMD, body length, and bone callus formation

Cho et al.³⁸

Wang et al.²⁹⁰