Fig. 8
From: Erythropoietin modulates bone marrow stromal cell differentiation
Schematic for erythropoietin regulation of BMSC differentiation. a EPO-EPOR signaling in BMSCs is required for maintaining the balance between osteogenic and adipogenic differentiation in the marrow. b Elevated EPO signaling in Tg6-mice inhibits both osteogenesis and adipogenesis. c Absence of endogenous EPO signaling in BMSCs in ΔEpoRE-mice reduces osteogenesis and favors adipogenesis resulting in fatty marrow. d EPO treatment in mice inhibits both osteogenesis and adipogenesis
