Fig. 4 | Bone Research

Fig. 4

From: Evading the host response: Staphylococcus “hiding” in cortical bone canalicular system causes increased bacterial burden

Fig. 4

Stainless steel disc and cancellous allograft histology. All images taken at ×200. ad Inoculated with 1 × 102 CFU S. aureus. eh Sterile control. a Acute inflammatory cells. b Acute inflammatory cells, no capsule. c No capsule, stroma tissue. d No capsule, stroma tissue. e Acute inflammatory cells. f Acute inflammatory cells, no capsule. g No capsule, stroma tissue. h No capsule, stroma tissue. Note in particular the presence of significant inflammatory cells throughout both infected and sterile specimens, but no evidence of cocci bacteria was discovered throughout. * = stromal tissue, + = capsule, white arrow = inflammatory cells. Cancellous allograft histology. il Inoculated with 1 × 102 CFU S. aureus. mp sterile control. i Thin capsule surrounding cancellous bone, neutrophils. j Thin capsule surrounding cancellous bone, neutrophils. k Thin capsule surrounding cancellous bone, neutrophils. l Thin capsule surrounding cancellous bone, neutrophils and eosinophils. m Thin capsule surrounding cancellous bone, minimal acute inflammatory cells. n Thin capsule surrounding cancellous bone, no acute inflammatory cells. o Thin capsule surrounding cancellous bone. p Thin capsule surrounding cancellous bone, some eosinophils. Note in particular the presence of inflammatory cells throughout both infected and sterile specimens, but no evidence of cocci bacteria was discovered throughout. * = bone, + = capsule, white arrow = inflammatory cells, blue arrowhead = cocci bacteria

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