Table 1 Characteristic data of type H, L and E endothelial cells
From: Skeleton-vasculature chain reaction: a novel insight into the mystery of homeostasis
Characteristics | Type H | Type L | Type E | References |
|---|---|---|---|---|
Marker expression | CD31hiEMCNhi | CD31loEMCNlo | CD31hiEMCNlo | |
Location | Endosteum and metaphysis | Diaphysis | Endosteum and compact bone | |
Morphology | Linearly structured, columnarly arranged vessels | Reticularly branched network | Linearly structured, columnarly arranged vessels | |
Surrounding cells | Osterix-expressing osteoprogenitor cells; PDGFR-β and NG2-expressing perivascular cells | Haematopoietic cells; CAR cells; PDGFR-a and LEPR-expressing perivascular cells | Osterix-expressing osteoprogenitor cells | |
Function | Mediate bone formation | Mediate haematopoietic process | Maintain bone formation | |
Blood celocity | High | Low | / | |
Oxygenation | Well oxygenated | Hypoxic | / | |
Permeability | Low | High | / | |
Relationship with aging | Reduction | No significant change | Rapid reduction during postnatal stages | |
Interconversion between different ECs | Type H→Type L; Type H→Arterial ECs | Type H→Type L | Type E→Type H; Type E→Arterial ECs |
