Fig. 3
Inhibitory effects of fluphenazine (FP) on tumorigenic behaviors of 4T1Br cells. CN control, FP fluphenazine, pl placebo, load tibial loading. The single and double asterisks indicate P < 0.05 and 0.01, respectively. a–c Reduction in MTT-assessed viability, EdU-measured proliferation, and the size of tumor spheroids induced by FP. d, e Decrease in the Transwell invasion and scratch assay migration after exposure to FP. f Reduction in the tumor area in the brain of BALB/c mice by daily tibial loading with and without FP administration. The whole-brain image and the H&E-stained coronal sections, including the maximum tumor area. The maximum tumor area in the coronal section was quantified, including the placebo and the tibia-loaded groups with and without FP administration (N = 6 per group)
