Fig. 4
Role of two dopamine receptors (DRD1 and DRD2) in the responses to dopamine and fluphenazine in 4T1Br cells. CN control, Dop dopamine, FP fluphenazine, siDRD1 DRD1 siRNA, siDRD2 DRD2 siRNA. The single and double asterisks indicate P < 0.05 and 0.01, respectively. a–c Suppression of dopamine-driven inhibition of MTT-assessed viability and scratch assay-measured migration upon the silencing of DRD1. The inhibitory effect of FP was not altered by DRD1 silencing. d–f Suppression of the FP-driven inhibition of MTT-assessed viability and scratch assay-measured migration upon the silencing of DRD2. The inhibitory effect of dopamine was not altered by DRD2 silencing. g Dopamine-driven downregulation of Snail, MMP9, and Runx2, and the abolishment of their downregulation by DRD1 silencing. h FP-driven downregulation of Snail, MMP9, and Runx2, and the abolishment of their downregulation by DRD2 silencing
