Fig. 1 | Bone Research

Fig. 1

From: An antibody against Siglec-15 promotes bone formation and fracture healing by increasing TRAP+ mononuclear cells and PDGF-BB secretion

Fig. 1

SKO mice exhibited increased bone formation and decreased bone resorption. a Representative three-dimensional µCT images of the trabeculae in the femurs of 3-month-old WT and SKO mice. Quantitative analysis of the µCT scan in a: b BV/TV percentage bone volume, c Tb. Th trabecular thickness, d Tb. N trabecular number, and e Tb. Sp trabecular separation. f Representative three-dimensional µCT images of the cortical bone in the femurs of 3-month-old WT and SKO mice. Quantitative analysis of the µCT scan in f: g BV bone volume, h Cor. Th cortical bone thickness, i Po (tot) total porosity. j Representative three-dimensional reconstructed µCT-based angiography of vessels in mouse femurs. k Quantitative analysis of vessel volume in j. VV vessel volume, TV tissue volume. l Double labeling of the mineral layers in mouse femur trabecular bone. m Quantitative analysis of the mineral apposition rate in l. n Trichrome staining of mouse femurs. The osteoid layer is labeled red. Quantitative analysis of the osteoid-covered surface (o) and osteoblast numbers (p). a–p n = 5, *P < 0.05, *P < 0.01, and ***P < 0.000 1 Error bar represents the standard error of the mean.

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